5/19/2025
Last update
5/19/2025
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.3
USERS' SCORE
Good
Based on 46 Reviews
8.7
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Sodium (from Sodium Hyaluronate)
10 mg
< 1 %
Hyaluronic Acid (from Sodium Hyaluronate)
100 mg
†
L-Proline (Free-Form)
100 mg
†
Alpha Lipoic Acid
50 mg
†
Grape Seed Extract (Vitis vinifera)(Standardized for Polyphenols)
25 mg
†
Top Medical Research Studies
8
Hyaluronic acid effectiveness evaluated
We explored how hyaluronic acid (HA) injections affect knee osteoarthritis (OA) pain and function. This study involved 128 patients, comparing the impact of a single high-dose injection to triple low-dose injections over 12 months.
Interestingly, the triple low-dose injections demonstrated better results, improving pain and function more effectively than the single high-dose approach.
So, for those dealing with knee OA, multiple, lower dose HA injections might be the way to go for relief.
Interestingly, the triple low-dose injections demonstrated better results, improving pain and function more effectively than the single high-dose approach.
So, for those dealing with knee OA, multiple, lower dose HA injections might be the way to go for relief.
Read More
8
LBSA0103 shows pain relief effectiveness
We aimed to understand how effective and safe LBSA0103, a highly cross-linked hyaluronic acid, is for treating knee osteoarthritis.
Involving over 3,140 participants, this study monitored side effects and pain relief through injections.
While some reported mild side effects, the majority experienced significant relief from knee pain, with more than 80% showing improvement after treatment.
Overall, LBSA0103 was well tolerated and demonstrated a positive effect on reducing pain, particularly in the weeks following treatment.
Involving over 3,140 participants, this study monitored side effects and pain relief through injections.
While some reported mild side effects, the majority experienced significant relief from knee pain, with more than 80% showing improvement after treatment.
Overall, LBSA0103 was well tolerated and demonstrated a positive effect on reducing pain, particularly in the weeks following treatment.
Read More
9
We explored the impact of hyaluronic acid (HA) sheet transplantation on knee pain in a rat arthritis model. This study administered HA sheets to right knees of rats following induced arthritis while left knees underwent sham surgery.
We observed significant pain relief and reduced inflammation in the knees treated with HA. Notably, these sheets decreased cartilage damage and fibrosis, offering hope for chronic knee pain management. However, the full extent of benefits needs further investigation in human subjects.
We observed significant pain relief and reduced inflammation in the knees treated with HA. Notably, these sheets decreased cartilage damage and fibrosis, offering hope for chronic knee pain management. However, the full extent of benefits needs further investigation in human subjects.
Read More
Most Useful Reviews
9
Knees no longer hurt
160 people found this helpful
This product is a wonderful source of vitality for the joints. After my treatment course, my knee pain has stopped, and the crunching in the joints has vanished.
Read More
9
Improved joint condition
95 people found this helpful
These medium-sized capsules are easy to take, and I've noticed the beneficial effect they have on my joints. With my post-traumatic arthritis, the crunch in my knee and unpleasant feelings during exertion have reduced.
Read More
9
Improved joint lubrication
23 people found this helpful
I’ve heard mixed reviews about this product, but I personally belong to those who see results. My skin condition has significantly improved, and the acne I've battled all my life has dissipated. Importantly, my knee pain has also lessened, as the hyaluronic acid lubricates my joints effectively, resulting in an overall positive experience.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.3
- All Researches
9
We explored the effectiveness of a treatment for knee osteoarthritis that combines oral duloxetine with an injection of hyaluronic acid and corticosteroid. Conducted at Beijing Tiantan Hospital, this study involved 150 patients who were randomly assigned to either the combined treatment or the injection alone.
After 24 weeks, results showed that those receiving the combination experienced a significant reduction in pain and improvement in knee function. However, it’s important to note that this study only assessed effects over a short term, so longer follow-ups will be necessary to determine lasting benefits.
After 24 weeks, results showed that those receiving the combination experienced a significant reduction in pain and improvement in knee function. However, it’s important to note that this study only assessed effects over a short term, so longer follow-ups will be necessary to determine lasting benefits.
Read More
9
We explored the effectiveness of hyaluronic acid injections for managing knee pain in patients with hemophilic arthropathy. Research indicated that a significant portion of participants experienced pain relief, with 91% reporting improvement over six years, and 82% of those with knee arthropathy seeing similar results after seven years. While findings varied across studies, it suggests that these injections can be beneficial for several months and can be repeated every six to twelve months. However, the overall data is somewhat diverse and complex.
Read More
9
We explored the impact of hyaluronic acid (HA) sheet transplantation on knee pain in a rat arthritis model. This study administered HA sheets to right knees of rats following induced arthritis while left knees underwent sham surgery.
We observed significant pain relief and reduced inflammation in the knees treated with HA. Notably, these sheets decreased cartilage damage and fibrosis, offering hope for chronic knee pain management. However, the full extent of benefits needs further investigation in human subjects.
We observed significant pain relief and reduced inflammation in the knees treated with HA. Notably, these sheets decreased cartilage damage and fibrosis, offering hope for chronic knee pain management. However, the full extent of benefits needs further investigation in human subjects.
Read More
8
We assessed the effects of a combination of hyaluronic acid and chondroitin sulfate on knee pain and mobility in a group of 21 patients. Over six months, participants reported a significant drop in pain levels, from near unbearable at 7.48 to a more manageable 5.24. Mobility also improved, showing a 35.61% increase by the six-month mark. Importantly, no serious side effects were noted. This treatment may enhance joint function and quality of life, easing daily activities for those with knee osteoarthritis.
Read More
8
Hyaluronic acid effectiveness evaluated
We explored how hyaluronic acid (HA) injections affect knee osteoarthritis (OA) pain and function. This study involved 128 patients, comparing the impact of a single high-dose injection to triple low-dose injections over 12 months.
Interestingly, the triple low-dose injections demonstrated better results, improving pain and function more effectively than the single high-dose approach.
So, for those dealing with knee OA, multiple, lower dose HA injections might be the way to go for relief.
Interestingly, the triple low-dose injections demonstrated better results, improving pain and function more effectively than the single high-dose approach.
So, for those dealing with knee OA, multiple, lower dose HA injections might be the way to go for relief.
Read More
User Reviews
USERS' SCORE
Good
Based on 46 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
9
Knees no longer hurt
160 people found this helpful
This product is a wonderful source of vitality for the joints. After my treatment course, my knee pain has stopped, and the crunching in the joints has vanished.
Read More
9
Improved joint condition
95 people found this helpful
These medium-sized capsules are easy to take, and I've noticed the beneficial effect they have on my joints. With my post-traumatic arthritis, the crunch in my knee and unpleasant feelings during exertion have reduced.
Read More
9
Improved joint lubrication
23 people found this helpful
I’ve heard mixed reviews about this product, but I personally belong to those who see results. My skin condition has significantly improved, and the acne I've battled all my life has dissipated. Importantly, my knee pain has also lessened, as the hyaluronic acid lubricates my joints effectively, resulting in an overall positive experience.
Read More
10
Avoids knee surgery
15 people found this helpful
The BEST!! Prior to starting this, my doctor recommended surgery for my knee. Now the fluid in my joints has increased so much that surgery is unnecessary. It's a fantastic product!!
Read More
10
Great joint health
9 people found this helpful
This product works wonders for joint health. In my 60s, as an elevator mechanic, stair walking and lifting have taken a toll on my knees. This hyaluronic acid has delivered excellent results where nothing else has. After two months of taking 200 mg daily, my knee joints are no longer a problem. Amazing! It’s a high-quality product, and I haven't experienced side effects. Definitely worth trying!
Read More
Frequently Asked Questions
10
Amazing supplement
2 people found this helpful
Miracle Supplement! Dad's knees ached for years, with thoughts of surgery. I read that hyaluronic acid could help, and it truly is a miracle. After two weeks of use, his knees stopped hurting.
9
Comfortable knees
2 people found this helpful
I take this twice daily for my knees. They used to ache constantly while walking and especially when using stairs. When I attempted to stop taking this product, my knees quickly returned to being painful within a week. This product is truly a lifesaver.
10
Great joint health
9 people found this helpful
This product works wonders for joint health. In my 60s, as an elevator mechanic, stair walking and lifting have taken a toll on my knees. This hyaluronic acid has delivered excellent results where nothing else has. After two months of taking 200 mg daily, my knee joints are no longer a problem. Amazing! It’s a high-quality product, and I haven't experienced side effects. Definitely worth trying!
10
Significant knee recovery
8 people found this helpful
I noticed positive effects for my knee joints. In summer 2017, I was diagnosed with chondromalacia of the knee cartilage. My knees were consistently painful after running and weightlifting, even at rest. I underwent a course involving glucosamine, chondroitin, and hyaluronic acid. After one and a half courses, my knees no longer hurt, allowing me to continue my workouts three to four times weekly. I hope that after a year of treatment, I will witness continued improvement. I highly recommend hyaluronic acid for joint and cartilage health.
9
Knees no longer hurt
160 people found this helpful
This product is a wonderful source of vitality for the joints. After my treatment course, my knee pain has stopped, and the crunching in the joints has vanished.
9
Improved joint condition
95 people found this helpful
These medium-sized capsules are easy to take, and I've noticed the beneficial effect they have on my joints. With my post-traumatic arthritis, the crunch in my knee and unpleasant feelings during exertion have reduced.
10
Avoids knee surgery
15 people found this helpful
The BEST!! Prior to starting this, my doctor recommended surgery for my knee. Now the fluid in my joints has increased so much that surgery is unnecessary. It's a fantastic product!!
9
Improved joint lubrication
23 people found this helpful
I’ve heard mixed reviews about this product, but I personally belong to those who see results. My skin condition has significantly improved, and the acne I've battled all my life has dissipated. Importantly, my knee pain has also lessened, as the hyaluronic acid lubricates my joints effectively, resulting in an overall positive experience.
9
Knee flexibility regained
5 people found this helpful
I believe this product has saved my knees! After experiencing discomfort and needing support due to bending difficulties, I tried hyaluronic acid alongside UC-II. I was sceptical at first, but I've regained my knee flexibility and feel as I did before. I will continue to take these and have recommended them to others.
7.5
Preventive care
3 people found this helpful
I take hyaluronic acid with collagen, spaced appropriately for optimal absorption. After a sports injury, my knees became vulnerable. I am pleased with the results and the product quality overall.
9
Joint crunching stopped
3 people found this helpful
This hyaluronic acid, which I take both alone and with collagen, has stopped the crunching in my knee joint while also benefitting my facial skin. I recommend it highly!
8
We assessed the effects of a combination of hyaluronic acid and chondroitin sulfate on knee pain and mobility in a group of 21 patients. Over six months, participants reported a significant drop in pain levels, from near unbearable at 7.48 to a more manageable 5.24. Mobility also improved, showing a 35.61% increase by the six-month mark. Importantly, no serious side effects were noted. This treatment may enhance joint function and quality of life, easing daily activities for those with knee osteoarthritis.
8
Hyaluronic acid effectiveness evaluated
We explored how hyaluronic acid (HA) injections affect knee osteoarthritis (OA) pain and function. This study involved 128 patients, comparing the impact of a single high-dose injection to triple low-dose injections over 12 months.
Interestingly, the triple low-dose injections demonstrated better results, improving pain and function more effectively than the single high-dose approach.
So, for those dealing with knee OA, multiple, lower dose HA injections might be the way to go for relief.
Interestingly, the triple low-dose injections demonstrated better results, improving pain and function more effectively than the single high-dose approach.
So, for those dealing with knee OA, multiple, lower dose HA injections might be the way to go for relief.
9
We explored the effectiveness of a treatment for knee osteoarthritis that combines oral duloxetine with an injection of hyaluronic acid and corticosteroid. Conducted at Beijing Tiantan Hospital, this study involved 150 patients who were randomly assigned to either the combined treatment or the injection alone.
After 24 weeks, results showed that those receiving the combination experienced a significant reduction in pain and improvement in knee function. However, it’s important to note that this study only assessed effects over a short term, so longer follow-ups will be necessary to determine lasting benefits.
After 24 weeks, results showed that those receiving the combination experienced a significant reduction in pain and improvement in knee function. However, it’s important to note that this study only assessed effects over a short term, so longer follow-ups will be necessary to determine lasting benefits.
8
We reviewed various intra-articular hyaluronic acid (IA-HA) products and their effects on knee osteoarthritis. This systematic analysis highlighted significant differences in the molecular size and source of these products, suggesting that high molecular weight (HMW) IA-HAs are more effective at reducing knee pain compared to low molecular weight (LMW) options.
However, we should note that some HMW products linked to avian sources or those that are cross-linked may lead to increased inflammation. So, while HMW IA-HA shows promise, careful consideration of product characteristics is essential for effective treatment.
However, we should note that some HMW products linked to avian sources or those that are cross-linked may lead to increased inflammation. So, while HMW IA-HA shows promise, careful consideration of product characteristics is essential for effective treatment.
We examined the effectiveness of hyaluronic acid (HA) alongside platelet-rich plasma (PRP) for treating anterior knee pain caused by chondromalacia patellae. In a study involving 43 patients, those receiving PRP and HA reported an improvement in pain and quality of life compared to a control group undergoing standard physiotherapy. Although previous studies showed mixed results, our findings support the combination treatment's potential to alleviate knee pain effectively. This suggests that HA may play a significant role in enhancing treatment outcomes for anterior knee pain.
References
- Dima A, Dragosloveanu M, Romila AR, Cristea A, Marinică G, et al. Can Hyaluronic Acid Combined with Chondroitin Sulfate in Viscosupplementation of Knee Osteoarthritis Improve Pain Symptoms and Mobility?. Biomolecules. 2024;14. 10.3390/biom14070832
- Ostojic M, Hakam HT, Lovrekovic B, Ramadanov N, Prill R. Treatment of anterior knee pain due to chondromalacia patellae with platelet-rich plasma and hyaluronic acid in young and middle-aged adults, a cohort study. Arch Orthop Trauma Surg. 2024;144:3969. 10.1007/s00402-024-05363-w
- Safali S, Ertaş ES, Özdemir A, Cataklı D. Evaluation of single and multiple hyaluronic acid injections at different concentrations with high molecular weight in the treatment of knee osteoarthritis. BMC Musculoskelet Disord. 2024;25:164. 10.1186/s12891-024-07200-y
- Li D, Hang R, Meng L, Zhao Z, Zhao C, et al. Co-treatment with Oral Duloxetine and Intraarticular Injection of Corticosteroid plus Hyaluronic Acid Reduces Pain in the Treatment of Knee Osteoarthritis. Pain Physician. 2024;27:E45.
- Rodriguez-Merchan EC. The role of intraarticular injections of hyaluronic acid in joint pain relief in hemophilic arthropathy. Expert Rev Hematol. 2023;16:811. 10.1080/17474086.2023.2271660
- Hill WS, Dohnalek MH, Ha Y, Kim SJ, Jung JC, et al. A Multicenter, Randomized, Double-Blinded, Placebo-Controlled Clinical Trial to Evaluate the Efficacy and Safety of a Krill Oil, Astaxanthin, and Oral Hyaluronic Acid Complex on Joint Health in People with Mild Osteoarthritis. Nutrients. 2023;15. 10.3390/nu15173769
- Colombini A, Doro G, Ragni E, Forte L, de Girolamo L, et al. Treatment with CR500® improves algofunctional scores in patients with knee osteoarthritis: a post-market confirmatory interventional, single arm clinical investigation. BMC Musculoskelet Disord. 2023;24:647. 10.1186/s12891-023-06754-7
- Kim JG, Kim KI, Park KB, Park YG, Bae JH, et al. Safety and effectiveness of intra-articular injection of a highly cross-linked hyaluronic acid, LBSA0103 (Synovian): Results from a post-marketing surveillance study in South Korea. PLoS One. 2023;18:e0287222. 10.1371/journal.pone.0287222
- Ferkel E, Manjoo A, Martins D, Bhandari M, Sethi P, et al. Intra-articular Hyaluronic Acid Treatments for Knee Osteoarthritis: A Systematic Review of Product Properties. Cartilage. 2023;14:424. 10.1177/19476035231154530
- Sconza C, Di Matteo B, Queirazza P, Dina A, Amenta R, et al. Ozone Therapy versus Hyaluronic Acid Injections for Pain Relief in Patients with Knee Osteoarthritis: Preliminary Findings on Molecular and Clinical Outcomes from a Randomized Controlled Trial. Int J Mol Sci. 2023;24. 10.3390/ijms24108788
- Saviola G, Da Campo G, Bianchini MC, Abdi-Ali L, Comini L, et al. Intra-articular clodronate in patients with knee osteoarthritis non-responder to intra-articular hyaluronic acid - a case report series of 9 patients with 8-month follow-up. Clin Ter. 2023;174:245. 10.7417/CT.2023.2528
- Qu Z, Koga H, Tsuji K, Tang G, Yang Y, et al. Hyaluronic acid sheet transplantation attenuates infrapatellar fat pad fibrosis and pain in a rat arthritis model. J Orthop Res. 2023;41:2442. 10.1002/jor.25580
- Küçükakkaş O, Aydin T, Yurdakul OV. Evaluation of the effect of intra-articular platelet-rich plasma and hyaluronic acid injections on femoral cartilage thickness in chronic knee osteoarthritis. Acta Orthop Belg. 2022;88:811. 10.52628/88.4.10243
- Mao B, Pan Y, Zhang Z, Yu Z, Li J, et al. Efficacy and Safety of Hyaluronic Acid Intra-articular Injection after Arthroscopic Knee Surgery: A Systematic Review and Meta-analysis. Orthop Surg. 2023;15:16. 10.1111/os.13602
- Arai T, Suzuki-Narita M, Takeuchi J, Tajiri I, Inage K, et al. Analgesic effects and arthritic changes following intra-articular injection of diclofenac etalhyaluronate in a rat knee osteoarthritis model. BMC Musculoskelet Disord. 2022;23:960. 10.1186/s12891-022-05937-y
